MovDisordV3, Main, Exploration, bibRecord, 005893

Hypokinesia in Parkinson's disease: Influence of age, disease severity, and disease duration

Identifieur interne : 005893 ( Main/Exploration ); précédent : 005892; suivant : 005894

Hypokinesia in Parkinson's disease: Influence of age, disease severity, and disease duration

Auteurs : van Hilten [Pays-Bas] ; E. A. M. Braat [Pays-Bas] ; E. A. Van Der Velde [Pays-Bas] ; H. A. M. Middelkoop [Pays-Bas] ; J. G. Van Dijk [Pays-Bas] ; G. J. Ligthart [Pays-Bas] ; R. A. C. Roos [Pays-Bas]

Source :

Movement Disorders [ 0885-3185 ] ; 1995-07.

RBID : ISTEX:9D4C31465078282E78D2D49E56E7963F2DCC414B

English descriptors

KwdEn :
- Activities of Daily Living (classification), Activity, Adult, Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Circadian Rhythm (drug effects), Circadian Rhythm (physiology), Drug Therapy, Combination, Female, Humans, Hypokinesia (classification), Hypokinesia (diagnosis), Hypokinesia (drug therapy), Immobility, Levodopa (therapeutic use), Male, Middle Aged, Motor Activity (drug effects), Motor Activity (physiology), Muscle Rigidity (classification), Muscle Rigidity (diagnosis), Muscle Rigidity (drug therapy), Neurologic Examination (drug effects), Parkinson Disease (classification), Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson's disease.
MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- classification : Activities of Daily Living, Hypokinesia, Muscle Rigidity, Parkinson Disease.
- diagnosis : Hypokinesia, Muscle Rigidity, Parkinson Disease.
- drug effects : Circadian Rhythm, Motor Activity, Neurologic Examination.
- drug therapy : Hypokinesia, Muscle Rigidity, Parkinson Disease.
- physiology : Circadian Rhythm, Motor Activity.
- Adult, Aged, Aged, 80 and over, Drug Therapy, Combination, Female, Humans, Male, Middle Aged.

Abstract

The aim of this cross‐sectional study was to compare the role of aging in measures reflecting diurnal activity and immobility in 60 parkinsonian patients with predominant features of hypokinesia and rigidity and 100 healthy subjects aged 50 to 98 years. In the patients, we also studied the relation between disease duration and subjective and objective measures of disease severity. Motor acitivity was recorded during 5 successive days at home with a wrist‐worn activity monitor. For each subject, two mean measures reflecting the diurnal activity level and the relative proportion of activity and immobility were calculated. Diurnal measures of activity revealed in both groups a prominent absolute reduction of activity and an increase of the time spent without movement (“immobility”) with advancing age. Parkinsonian patients showed significantly lower values for both motor‐activity measures than did the healthy subjects. The rate of the age‐related decline of both diurnal activity measures in both groups, however, is comparable. Disease duration showed no relation with subjective and objective measures reflecting disease severity. This study shows that if care is taken to control for disease severity, the rate of the age‐related decline of measures reflecting diurnal activity and immobility is similar in both groups. The lack of relation between disease duration and subjective and objective measures of disease severity suggests that the rate of progression of Parkinson's disease can be reliably studied only by means of longitudinal studies.

Url:

https://api.istex.fr/document/9D4C31465078282E78D2D49E56E7963F2DCC414B/fulltext/pdf

DOI: 10.1002/mds.870100404

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">The aim of this cross‐sectional study was to compare the role of aging in measures reflecting diurnal activity and immobility in 60 parkinsonian patients with predominant features of hypokinesia and rigidity and 100 healthy subjects aged 50 to 98 years. In the patients, we also studied the relation between disease duration and subjective and objective measures of disease severity. Motor acitivity was recorded during 5 successive days at home with a wrist‐worn activity monitor. For each subject, two mean measures reflecting the diurnal activity level and the relative proportion of activity and immobility were calculated. Diurnal measures of activity revealed in both groups a prominent absolute reduction of activity and an increase of the time spent without movement (“immobility”) with advancing age. Parkinsonian patients showed significantly lower values for both motor‐activity measures than did the healthy subjects. The rate of the age‐related decline of both diurnal activity measures in both groups, however, is comparable. Disease duration showed no relation with subjective and objective measures reflecting disease severity. This study shows that if care is taken to control for disease severity, the rate of the age‐related decline of measures reflecting diurnal activity and immobility is similar in both groups. The lack of relation between disease duration and subjective and objective measures of disease severity suggests that the rate of progression of Parkinson's disease can be reliably studied only by means of longitudinal studies.</div>
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Movement Disorders (revue)

Hypokinesia in Parkinson's disease: Influence of age, disease severity, and disease duration

Hypokinesia in Parkinson's disease: Influence of age, disease severity, and disease duration

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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